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The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups
1Wyeth-Ayerst Research, 401 N. Middletown Rd., Pearl River, NY 10965, USA. levinji@war.wyeth.com
Bioorganic & Medicinal Chemistry Letters
|August 22, 2001
Abstract:
A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, MMP-13, and TACE was prepared and evaluated. Selective inhibitors of MMP-9, MMP-13, and TACE were identified, including the potent, orally active MMP-13 inhibitor 4p.
