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Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle?

P R Clarke1, C Zhang

  • 1Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY, Dundee, UK. p.clarke@icrf.icnet.uk

Trends in Cell Biology
|August 22, 2001
PubMed
Summary

Ran GTPase is crucial for nuclear transport and cell division. It coordinates nuclear envelope formation and mitotic spindle assembly through interactions with importins, utilizing common biochemical mechanisms.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Ran is a highly conserved GTPase in eukaryotic cells.
  • It plays a key role in nucleocytoplasmic transport during interphase.
  • Recent studies suggest distinct roles in mitosis.

Purpose of the Study:

  • To review advances in understanding Ran's roles beyond interphase transport.
  • To discuss Ran's function in mitotic spindle assembly and nuclear envelope formation.
  • To present a general model for Ran's coordination of cell division processes.

Main Methods:

  • Review of existing literature and cell-free system studies.
  • Analysis of Ran's interactions with importins during mitosis.
  • Biochemical mechanism-based modeling.

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Main Results:

  • Ran influences mitotic spindle assembly and nuclear envelope formation in vitro.
  • Ran controls importin complex formation during spindle assembly.
  • Common biochemical mechanisms link Ran's functions across the cell cycle.

Conclusions:

  • Ran GTPase is a central coordinator of nuclear processes throughout the cell cycle.
  • Ran's functions in nuclear transport and cell division are mechanistically linked.
  • A unified model explains Ran's diverse roles via common effector interactions.