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Related Concept Videos

Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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The Utility of Stage-specific Mid-to-late Drosophila Follicle Isolation
08:44

The Utility of Stage-specific Mid-to-late Drosophila Follicle Isolation

Published on: December 3, 2013

Follicle selection in monovular species.

O J Ginther1, M A Beg, D R Bergfelt

  • 1Department of Animal Health and Biomedical Sciences, University of Wisconsin, 1656 Linden Drive, Madison, WI 53706, USA. ojg@ahabs.wisc.edu

Biology of Reproduction
|August 22, 2001
PubMed
Summary
This summary is machine-generated.

Follicle deviation, a key event in selecting a dominant follicle, is driven by a follicle-coupling mechanism. This process involves follicle-stimulating hormone (FSH) and luteinizing hormone (LH) interactions, ensuring only the largest follicle matures.

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Area of Science:

  • Reproductive Biology
  • Endocrinology
  • Veterinary Science

Background:

  • Follicle selection is crucial for reproduction in monovular species.
  • The deviation phase, where one follicle becomes dominant, is critical.
  • Existing hypotheses suggest a complex interplay of hormones and follicle development.

Purpose of the Study:

  • To elucidate the mechanism of follicle selection in cattle, focusing on the deviation phase.
  • To investigate the role of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in dominant follicle selection.
  • To understand the hormonal and cellular events leading to the establishment of follicular dominance.

Main Methods:

  • Analysis of follicle diameters and hormonal profiles (FSH, inhibin, estradiol) during the deviation period.
  • Investigation of luteinizing hormone (LH) surge characteristics and LH receptor presence in granulosa cells.
  • Correlation of intrafollicular factors (estradiol, insulin-like growth factor-1) with FSH responsiveness.

Main Results:

  • Follicle deviation in cattle is established within 8 hours, initiated by the largest follicle's dominance.
  • An FSH:follicle-coupling hypothesis is supported, involving FSH decline modulated by inhibin and estradiol.
  • LH surge and LH receptor appearance precede deviation, with LH stimulating estradiol and IGF-1 production in the dominant follicle.

Conclusions:

  • Follicle selection is established through a dynamic hormonal interplay, primarily involving FSH and LH.
  • The dominant follicle's advanced development allows it to utilize low FSH concentrations, while smaller follicles become susceptible.
  • This mechanism ensures the selection of a single dominant follicle capable of ovulation.