Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neural abnormalities in the dystrophic mouse.

W G Bradley, M Jenkison

    Journal of the Neurological Sciences
    |June 1, 1975
    PubMed
    Summary

    Neural abnormalities, specifically amyelination, were observed in cranial nerves and spinal nerve roots of Bar Harbor dystrophic mice. These findings highlight potential mechanisms in both severe and benign forms of this muscular dystrophy model.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    In vivo prostate cancer detection and grading using restriction spectrum imaging-MRI.

    Prostate cancer and prostatic diseases·2016
    Same author

    Intracranial Pressure versus Phase-Contrast MR Imaging for Normal Pressure Hydrocephalus.

    AJNR. American journal of neuroradiology·2015
    Same author

    Novel technique for characterizing prostate cancer utilizing MRI restriction spectrum imaging: proof of principle and initial clinical experience with extraprostatic extension.

    Prostate cancer and prostatic diseases·2015
    Same author

    CSF Flow in the Brain in the Context of Normal Pressure Hydrocephalus.

    AJNR. American journal of neuroradiology·2014
    Same author

    Current and emerging MR imaging techniques for the diagnosis and management of CSF flow disorders: a review of phase-contrast and time-spatial labeling inversion pulse.

    AJNR. American journal of neuroradiology·2014
    Same author

    Acute-onset migrainous aura mimicking acute stroke: MR perfusion imaging features.

    AJNR. American journal of neuroradiology·2012

    Area of Science:

    • Neuroscience
    • Animal Models of Disease
    • Genetics

    Background:

    • Bar Harbor dystrophic mice (dy/dy) are a widely used model for studying muscular dystrophy.
    • Previous research has identified various genetic and cellular defects in these mice.
    • The precise nature of neural involvement in dystrophic mice requires further elucidation.

    Purpose of the Study:

    • To investigate neural abnormalities in Bar Harbor dystrophic mice.
    • To characterize the extent and location of demyelination in affected nerves.
    • To compare neural findings between severe (129 Re/J dy/dy) and benign (dy-2J DY-2J) dystrophic mouse models.

    Main Methods:

    • Histological examination of cranial nerves, ventral cervical, and lumbosacral roots.
    • Analysis of mixed spinal nerves.
    • Comparative study across different genetic forms of Bar Harbor dystrophic mice.

    Main Results:

    • Evidence of amyelination (loss of myelin) was detected in the cranial nerves.
    • Demyelination was also observed in the ventral cervical and lumbosacral nerve roots.
    • Abnormalities in mixed spinal nerves were identified in both severe and benign dystrophic mouse forms.

    Conclusions:

    • Neural abnormalities, characterized by amyelination, are a feature of Bar Harbor dystrophic mice.
    • These findings suggest a broader impact of the dystrophin mutation beyond skeletal muscle.
    • The study contributes to understanding the pathomechanisms underlying dystrophinopathies.

    Related Experiment Videos