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Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model
Published on: November 24, 2014
Experimental evaluation of a modified Amplatzer duct occluder
1Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA. kongx014@tc.umn.edu
Summary
A new device for patent ductus arteriosus (PDA) occlusion demonstrated high success rates in canine models. This innovative implant showed promising results for percutaneous closure of aortopulmonary shunts.
Area of Science:
- Cardiovascular Surgery
- Medical Device Innovation
- Veterinary Cardiology
Background:
- Patent ductus arteriosus (PDA) is a congenital heart defect requiring occlusion.
- Existing devices for PDA closure have limitations.
- Anatomically tailored devices may improve occlusion outcomes.
Purpose of the Study:
- To evaluate a novel device designed for PDA occlusion based on anatomical considerations.
- To assess the safety and efficacy of this new device in a canine model.
- To compare the new device with existing standard occluders.
Main Methods:
- Surgically created aortopulmonary shunts mimicking PDA in 10 dogs.
- Deployment of a new occlusion prosthesis with a cylindrical frame and angled retention disk.
- Percutaneous delivery using a 6 Fr sheath, antirotating catheter, and cable.
Main Results:
- Complete shunt occlusion achieved in 9 out of 10 animals.
- One animal mortality occurred prior to device placement.
- Temporary hemolysis in one dog; complete neoendothelial coverage observed at 1-3 months postmortem.
- No device protrusion into the aortic lumen; flat disk placement minimizing turbulence and pressure gradients.
Conclusions:
- The new PDA occlusion device is effective and safe in a canine model.
- The anatomically designed angled retention disk offers advantages over standard devices.
- This device represents a potential improvement for percutaneous closure of aortopulmonary shunts.
