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Updated: Oct 5, 2026

Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells
Published on: February 20, 2015
Apoptotic UV-irradiated lymphocytes undergo protease mediated shedding of L-selectin in vitro
P M Kern1, L Keilholz, J R Kalden
1Department of Internal Medicine/Rheumatology, Franz von Pruemmer Klinik, Bad Brueckenau, Germany.
Abstract:
Adhesion between circulating lymphocytes and endothelial cells of the vessel wall depends on the expression of selectins and is the first step of tissue invasion which characterises inflammation. UV-B is well known to induce apoptosis in lymphocytes. We show that induction of apoptosis by any procedure leads to a metalloprotease mediated shedding of L-selectin from the surface of T-lymphocytes. Together with the previously published immunosuppressive action of apoptotic cells, this may contribute to the clinical effect of UV-B application, especially in photopheresis.
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