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Related Experiment Videos

Mast cells as a source and target for nitric oxide.

M Bidri1, F Féger, S Varadaradjalou

  • 1Department of Cellular and Molecular Hematology, UPRES-EA 2509, Faculty of Pharmaceutical and Biological Sciences, Paris, France.

International Immunopharmacology
|August 23, 2001
PubMed
Summary

Mast cells (MC) produce nitric oxide (NO) derivatives, influencing nearby cells. Further research is needed to understand NO

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Area of Science:

  • Immunology
  • Cell Biology
  • Biochemistry

Background:

  • Mast cells (MC) are tissue-resident immune cells derived from hematopoietic stem cells.
  • MC release various bioactive mediators like histamine, proteases, cytokines, and chemokines.
  • Rodent MC can produce nitric oxide (NO) derivatives, influencing nearby cell functions.

Purpose of the Study:

  • To explore the role of nitric oxide (NO) in mast cell (MC) biology.
  • To investigate the cross-talk between MC and NO in human and rodent systems.
  • To assess the potential for NO pathway modulation in MC-related conditions.

Main Methods:

  • Review of existing literature on mast cells and nitric oxide synthesis.
  • Analysis of nitric oxide synthase (NOS) expression in MC.

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  • Examination of NO's impact on MC survival and reactivity.

    • Main Results:

    • Rodent MC can synthesize NO spontaneously or upon activation, regulated by iNOS and nNOS.
    • NO produced by MC can influence the survival and function of adjacent NO-sensitive cells.
    • NO also affects rodent MC survival and reactivity, creating a feedback loop.

    Conclusions:

    • Mast cells are implicated in nitric oxide (NO) production and signaling.
    • The cross-talk between MC and NO is well-documented in rodents but less so in humans.
    • Targeting the NO pathway offers potential therapeutic strategies for MC-mediated diseases.