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Polymeric microspheres composed of pH/temperature-sensitive polymer complex
1Advanced Materials Division, Korea Research Institute of Chemical Technology, Yusung, Taejeon, South Korea.
Biomaterials
|August 23, 2001
Summary
A novel polymer system using poly(N,N-dimethylamino)ethyl methacrylate (DMAEMA) and polyethyl acrylamide (EAAm) enables controlled drug release. This pH/temperature-sensitive material offers on-off hydrocortisone delivery with minimal delay.
Area of Science:
- Polymer Science
- Materials Science
- Drug Delivery Systems
Background:
- Developing smart materials for targeted drug delivery is crucial.
- pH and temperature-sensitive polymers offer tunable release profiles.
- Existing systems may have limitations in responsiveness or lag time.
Purpose of the Study:
- To create a dual pH/temperature-sensitive polymer system.
- To design and characterize microspheres for controlled drug release.
- To evaluate the release kinetics of hydrocortisone from the developed system.
Main Methods:
- Synthesized a polymer mixture of poly(N,N-dimethylamino)ethyl methacrylate (DMAEMA) and polyethyl acrylamide (EAAm).
- Fabricated drug-loaded microspheres using the polymer system.
- Characterized microsphere properties and performed drug release studies under varying pH and temperature conditions.
- Utilized hydrocortisone as a model drug for release evaluation.
Main Results:
- The polymer system exhibited transitions due to both polymer-water and polymer-polymer interactions.
- Microspheres demonstrated pH/temperature-sensitive release behavior.
- Controlled on-off release of hydrocortisone was achieved.
- Release occurred without a considerable lag time.
Conclusions:
- The DMAEMA/EAAm polymer mixture forms an effective pH/temperature-sensitive system.
- Microspheres derived from this system are suitable for controlled drug delivery.
- The system allows for precise, on-off release of hydrocortisone, minimizing delays.