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Related Experiment Videos

Effect of compaction on particle size.

K A Khan, C T Rhodes

    Journal of Pharmaceutical Sciences
    |March 1, 1975
    PubMed
    Summary

    Tablet compaction pressure significantly impacts disintegrant particle size, regardless of the initial material. Understanding particle size changes reveals insights into the compaction process for pharmaceutical formulations.

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    Area of Science:

    • Pharmaceutical Sciences
    • Materials Science
    • Chemical Engineering

    Background:

    • Tablet disintegration is crucial for drug efficacy.
    • The compaction process influences tablet properties, including disintegration.
    • Particle size of excipients affects tablet performance.

    Purpose of the Study:

    • To investigate the effect of compaction pressure on the particle-size distribution of disintegrating tablets.
    • To compare the disintegration behavior of different pharmaceutical excipients under varying compaction forces.
    • To establish a relationship between compaction parameters and the resulting particle size of disintegrated materials.

    Main Methods:

    • Tablets were prepared using aspirin, dicalcium phosphate dihydrate, calcium phosphato-carbonate, alumina, and microcrystalline cellulose.
    • Compaction was performed using a hydraulic press at various pressures with a standardized technique.
    • Disintegrants (cation-exchange resin) were included in all formulations except microcrystalline cellulose.
    • Particle-size spectra of disintegrating compacts were analyzed using a particle-size counter and air jet sieve.

    Main Results:

    • Compact materials with identical initial particle-size spectra yielded significantly different particle sizes upon disintegration.
    • Compaction pressure influenced the final particle size distribution of the disintegrated tablet components.
    • The study demonstrated that the nature of the material significantly affects disintegration particle size.

    Conclusions:

    • The compaction process fundamentally alters particle characteristics, leading to varied disintegration particle sizes.
    • Analyzing changes in particle size post-compaction offers valuable insights into the compression behavior of pharmaceutical solids.
    • Material properties play a critical role in determining disintegration outcomes, even when initial particle sizes are uniform.

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