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Continual replacement of newly-generated olfactory neurons in adult rats
T Kato1, K Yokouchi, N Fukushima
1Department of Anatomy, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
Neuroscience Letters
|August 23, 2001
Abstract:
It has been known that stem cells do exist in the central nervous system, and adult neurogenesis is continually taking place in the olfactory bulb during life. We report here, with the combined method of autoradiography using (3)H-thymidine and immunohistochemistry for a neuronal marker, that 65.3-76.9% of calretinin-immunoreactive bulbar neurons are replaced during the short period of 6 weeks in the adult rodent. The results indicate that neuronal replacement is a common phenomenon in the olfactory bulb during life.