Neurobiology of fish olfaction: a review

The last decade saw important advances in our understanding of the olfactory system function. In some animals, we now have the basic knowledge necessary to investigate coding mechanisms employed in olfaction. So far, studies of the fish olfactory system have focused on odor detection and the early processing of olfactory information in the olfactory bulb. How this information is integrated in the forebrain is unknown. Here, we first describe the anatomy of the fish olfactory system. The problems faced when describing the anatomy of the terminal nerve complex and nucleus olfactoretinalis are highlighted. Olfactory sensory neurons are randomly distributed over the entire olfactory epithelium, a unique feature of the olfactory sense. These primary olfactory neurons converge upon their second-order targets in segregated areas of the olfactory bulb. Exchange of information occurs in the glomeruli and glomerular plexus, where primary neurons synapse on mitral cell dendrites. The spatial distribution of glomerular activity induced by odorants of different classes shows that distinct neuron populations of the olfactory bulb encode information related to different odorant groups. In most cases, these neuron populations synchronize their alternating sequences of firing and silence when stimulated by primary input. Synchronized oscillations of these second-order neurons could contain important coding information, or represent a mechanism by which learning is facilitated. Alternatively, oscillations could be solely used to shape the olfactory bulb response. The nature of the olfactory information that reaches the forebrain and decoding of this information by the central nervous system are discussed.