Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nasal vaccination using live bacterial vectors.

N Mielcarek1, S Alonso, C Locht

  • 1INSERM U447, IBL, Institut Pasteur of Lille, 1 Rue du Pr. Calmette, 59019, Lille, France.

Advanced Drug Delivery Reviews
|August 23, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiparametric analysis of vaccine-induced B and T cell responses for optimal evaluation of memory immune responses to Bordetella pertussis in children.

Vaccine·2026
Same author

Prevalence of acquired resistance to antiretrovirals in children and adolescents living with HIV under clinical follow-up at the Roosevelt Hospital in Guatemala.

Journal of infection and public health·2025
Same author

Preoperative radiosurgery for brain metastases (PREOP-1): A feasibility trial.

Clinical and translational radiation oncology·2024
Same author

Country-report pattern corrections of new cases allow accurate 2-week predictions of COVID-19 evolution with the Gompertz model.

Scientific reports·2024
Same author

Impact of malnutrition on the quality of life in older patients with advanced heart failure: a cohort study.

Revista clinica espanola·2024
Same author

Infection control in long term care institutions for the elderly: A reflection document on the situation in Spain.

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia·2023

Live recombinant bacteria offer a promising approach for inducing immune responses. This review explores different types of engineered bacteria for intranasal immunization, focusing on antigen expression and immunogenicity.

Area of Science:

  • * Immunology and Microbiology
  • * Vaccine Development

Background:

  • * Live recombinant bacteria are effective for inducing mucosal and systemic immunity against foreign antigens.
  • * Intranasal immunization using these bacterial vectors has demonstrated high efficiency in various models.

Purpose of the Study:

  • * To review the main classes of live recombinant bacteria used in immunization.
  • * To discuss strategies for heterologous antigen expression, bacterial invasiveness, and immunogenicity.

Main Methods:

  • * Categorization of live recombinant bacteria into generally recognized as safe (GRAS) and attenuated pathogenic strains.
  • * Differentiation of attenuated strains based on their respiratory tract colonization potential.
  • * Analysis of antigen expression strategies and their impact on immune response.

Related Experiment Videos

Main Results:

  • * Live recombinant bacteria, particularly those administered intranasally, are potent inducers of immune responses.
  • * The choice between GRAS and attenuated bacteria, along with their specific adaptations and antigen presentation methods, influences immunogenicity.
  • * Bacterial invasiveness and tissue tropism are critical factors in the efficacy of intranasal immunization.

Conclusions:

  • * Live recombinant bacteria represent a versatile platform for developing vaccines against various antigens.
  • * Optimizing antigen expression, bacterial invasiveness, and host immune interactions is key to maximizing vaccine efficacy.
  • * Further research into bacterial strain selection and engineering strategies will advance the field of mucosal and systemic immunization.