Related Experiment Video
Updated: Jul 18, 2026

Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump
Published on: March 11, 2017
Voltammetric determination of nilvadipine in dosage forms and spiked human urine
1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. ffbelal@ksu.edu.sa
Abstract:
The voltammetric behaviour of nilvadipine was studied adopting direct-current, differential-pulse and alternating current polarography. Nilvadipine-being nitroderivative-exhibited well-defined cathodic waves over the whole pH range in Britton-Robinson buffers. At pH 5, the diffusion-current constant, (Id) was 4.78. The current-concentration plots are rectilinear over the range 1.5-20 and 0.2-10 microg/ml using the direct current and differential pulse-polarographic techniques with minimum detectability of 0.05 microg/ml (1.3 x 10(-7) M) using the latter technique. The proposed method was applied to commercial capsules containing the drug. The percentage recoveries were in agreement with those obtained by a reference method. Furthermore, the method was applied to spiked human urine, the percentage recovery was 95.54+/-2.137.
More Related Videos
08:41Integration of Miniaturized Solid Phase Extraction and LC-MS/MS Detection of 3-Nitrotyrosine in Human Urine for Clinical Applications
Published on: July 14, 2017
10:17High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Related Concept Videos
Voltammetric Techniques: Linear-Scan (E vs Time)
Voltammetric Techniques: Pulse Voltammetry
One-Compartment Open Model: Urinary Excretion Data and Determination of k
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Therapeutic Drug Monitoring: Drug Analysis Methods
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant