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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
In vitro antifungal activity of posaconazole against various pathogenic fungi
K Uchida1, N Yokota, H Yamaguchi
1Institute of Medical Mycology, Teikyo University, 359 Otsuka, Hachioji, 192-0395 Tokyo, Japan. kuchida@main.teikyo-u.ac.jp
Abstract:
The antifungal activity of posaconazole (SCH56592), a new triazole antifungal, against stock cultures and fresh clinical isolates of a wide range of pathogenic fungi was compared with that of itraconazole, fluconazole and amphotericin B. Posaconazole inhibited growth of all the fungal species tested except Fusarium spp. at 1 mg/l or lower concentrations, showing a broad-spectrum antifungal activity. The activities of posaconazole for all the fungal species far surpassed those of fluconazole and were even superior to those of itraconazole for Aspergillus spp. as well as for many other fungal species.
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