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Related Experiment Videos

Dopamine-dependent synaptic plasticity in the striatal cholinergic interneurons.

T Suzuki1, M Miura, K Nishimura

  • 1Department of the Autonomic Nervous System, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173-0015, Japan.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|August 23, 2001
PubMed
Summary

Researchers discovered that stimulating mouse corticostriatal slices induces long-term potentiation (LTP) in excitatory and inhibitory synapses of striatal cholinergic interneurons, revealing key mechanisms for synaptic plasticity.

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Area of Science:

  • Neuroscience
  • Cellular and Molecular Biology
  • Synaptic Plasticity

Background:

  • The striatum, a key basal ganglia component, is vital for habit learning and skill acquisition.
  • Dopamine (DA) and acetylcholine (ACh) are crucial for implicit memory, but cellular mechanisms remain elusive.
  • Cholinergic interneurons in the striatum play a significant role in modulating synaptic transmission.

Purpose of the Study:

  • To investigate long-term synaptic changes in identified striatal cholinergic interneurons.
  • To determine the effects of tetanic stimulation on cortico- and thalamostriatal fibers.
  • To elucidate the cellular mechanisms underlying synaptic plasticity in the striatum.

Main Methods:

  • Patch-clamp recordings were performed on corticostriatal slices from mice.

Related Experiment Videos

  • Tetanic stimulation was applied to cortico- and thalamostriatal fibers.
  • Postsynaptic potentials (EPSPs and IPSPs) in cholinergic interneurons were analyzed.

    • Main Results:

    • Tetanic stimulation induced simultaneous long-term potentiation (LTP) of glutamatergic EPSPs and disynaptic GABAergic IPSPs.
    • LTP induction required intracellular Ca(2+) and dopamine D(5) receptor activation, not D(2) receptors.
    • Enhanced disynaptic IPSPs resulted from an increased occurrence rate, not amplitude, in cholinergic interneurons.

    Conclusions:

    • Striatal cholinergic interneurons exhibit dual synaptic plasticity mechanisms (LTP of EPSPs and enhanced IPSPs).
    • This plasticity is modulated by Ca(2+) influx and dopamine D(5) receptor signaling.
    • These findings offer insights into the cellular basis of implicit memory and skill learning in the striatum.