Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Intravascular lymphomatosis: a case report].

H Adachi1, M Tsuboi, K Hayashi

  • 1Department of Neurosurgery, Bizen Municipal Hospital, 2245 Ibe, Bizen-city, Okayama 705-0001, Japan.

No Shinkei Geka. Neurological Surgery
|August 24, 2001
PubMed
Summary

Intravascular lymphomatosis is a rare condition causing neurological issues like dementia and seizures. Early diagnosis is challenging but suggested by brain imaging and elevated biomarkers, confirmed by biopsy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[A gastric cancer showing an exclusive metastatic nest at the gastroenemius muscle].

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology·1998
Same author

Usefulness of extracorporeal membrane oxygenation for treatment of fulminant myocarditis and circulatory collapse.

The American journal of cardiology·1998
Same author

Detection of adrenal and retroperitoneal masses in a general health examination system.

Urology·1998
Same author

[Concomitant cardiac and pulmonary operation, the profits of not using cardio-pulmonary bypass].

Kyobu geka. The Japanese journal of thoracic surgery·1998
Same author

Restoration of sexual behavior and dopaminergic neurotransmission by long term exogenous testosterone replacement in aged male rats.

The Journal of urology·1998
Same author

[Postoperative follow-up of acute aortic dissection and the result of second operations].

Kyobu geka. The Japanese journal of thoracic surgery·1998

Area of Science:

  • Neurology
  • Oncology
  • Pathology

Background:

  • Intravascular lymphomatosis (IVL) is a rare extranodal non-Hodgkin lymphoma characterized by proliferation of lymphoid cells within small blood vessels.
  • Diagnosis can be challenging due to nonspecific symptoms and the deep-seated nature of the lesions.

Observation:

  • A 64-year-old male presented with dementia, seizures, and neurological deficits attributed to multiple cerebral infarctions on imaging.
  • Progressive high fever, convulsions, elevated serum lactate dehydrogenase (LDH), and high beta-2 microglobulin in serum and cerebrospinal fluid (CSF) were noted.

Findings:

  • Histopathological examination via open biopsy confirmed intravascular lymphomatosis of the large B-cell type.
  • Treatment with M-CHOP chemotherapy led to clinical improvement and reduction of biomarkers, but the patient ultimately succumbed to respiratory failure.

Related Experiment Videos

Implications:

  • Early diagnosis of IVL is difficult, necessitating a high index of suspicion.
  • Neuroradiological findings of multiple cerebral infarctions, coupled with elevated serum LDH (particularly LDH2 and LDH3) and beta-2 microglobulin, suggest IVL.
  • Biopsy remains crucial for definitive diagnosis and guiding treatment strategies for this aggressive lymphoma.