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[Thrombolysis in cerebral ischemia. An overview]
P D Schellinger1, J Fiebach, P A Ringleb
1Neurologische Klinik des Universitätsklinikum Heidelberg, im Neuenheimer Feld 400, Kopfklinik, 69120 Heidelberg. Peter_Schellinger@med.uni-heidelberg.de
Der Nervenarzt
|August 25, 2001
Summary
Thrombolytic therapy for acute ischemic stroke is approved but underutilized. This review covers trials and recommendations to improve treatment rates for stroke patients.
Area of Science:
- Neurology
- Cardiovascular Medicine
- Emergency Medicine
Context:
- Acute ischemic stroke treatment guidelines.
- FDA-approved thrombolytic therapy for stroke.
- Low patient utilization rates (<2%) in the US.
Purpose:
- Review completed intravenous and intra-arterial thrombolytic therapy trials.
- Provide recommendations for stroke therapy and diagnostics.
- Analyze patient selection, meta-analyses, phase IV trials, and cost-effectiveness.
Summary:
- Comprehensive review of thrombolytic therapy trials for carotid and vertebrobasilar artery strokes.
- Examines diagnostic procedures and their impact on patient selection.
- Includes meta-analyses, phase IV trials, and cost-efficacy analyses for informed decision-making.
Impact:
- Aims to increase the adoption of effective thrombolytic therapy for acute ischemic stroke.
- Highlights the need for improved patient selection and treatment protocols.
- Informs clinical practice and healthcare policy regarding stroke management.