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Updated: Jul 31, 2026

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies
Published on: January 31, 2013
[Proximal weakness and exercise-induced pain as initial symptom of oculopharyngeal muscular dystrophy]
J B Lampe1, J Schäfer, H J Gärtner
1Klinik für Neurologie, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden.
Abstract:
A 54-year-old female patient presented with exercise-induced proximal muscle pain and weakness of the lower limbs. One year after the onset of these symptoms she developed bilateral ptosis and dysphagia. Molecular genetic analysis of the poly(A) binding protein 2 gene (PABP2) confirmed the presumptive diagnosis of oculopharyngeal muscular dystrophy (OPMD). Exercise-induced proximal muscle pain and weakness are rarely initial symptoms of OPMD. We discuss therapeutic options and present an overview of the relevant literature.
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