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Anti-herpes viruses agents.

N M Abdel-Haq¹, B I Asmar

¹Devision of Infectious Diseases, Children's Hospital of Michigan, Wayne State University, School of Medicine, Detroit, Michigan, USA.

Indian Journal of Pediatrics

|August 25, 2001

Summary

Effective antiviral drugs manage herpes virus infections in children, including new agents targeting resistant strains. This review covers their use, pharmacology, and indications for treating herpes simplex virus (HSV), VZV, and CMV in pediatric patients.

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Area of Science:

Pediatric infectious diseases
Virology
Pharmacology

Background:

Antiviral agents are crucial for managing herpes virus infections in children.
Herpes viruses like HSV-1, HSV-2, VZV, and CMV pose significant health risks to pediatric populations.
Existing treatments demonstrate efficacy, but challenges remain, particularly with resistant viral strains.

Purpose of the Study:

To review antiviral agents for herpes virus infections in children.
To focus on the activity, clinical pharmacology, and indications of these agents.
To highlight recent advancements in newer antiviral drugs effective against resistant strains.

Main Methods:

Literature review of antiviral agents.
Analysis of clinical pharmacology and efficacy data.
Focus on pediatric applications for herpes virus infections.

Main Results:

Established antiviral agents are available for HSV-1, HSV-2, VZV, and CMV infections in children.
Newer agents show enhanced activity, including against resistant herpes virus strains.
The review details the clinical pharmacology and indications for these pediatric treatments.

Conclusions:

A range of effective antiviral therapies exists for pediatric herpes virus infections.
Ongoing research yields agents with improved activity against resistant strains.
This review provides a comprehensive overview for clinicians managing these infections in children.

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