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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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[Effects of korinfar-retard on parameters for the left ventricular diastolic function in patients with hypertensive

N Iu Sydorova, V K Sierkova, Iu I Monastyrskyĭ

    Likars'Ka Sprava
    |August 25, 2001
    PubMed

    Insights

    Corinfarretard improved diastolic dysfunction in patients with disordered relaxation type, enhancing temporal diastolic patterns. However, it showed no significant impact on restrictive type diastolic dysfunction.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Diastolic dysfunction, specifically disordered relaxation and restrictive types, affects left ventricular function.
    • Understanding the impact of pharmacological interventions on diastolic dysfunction is crucial for patient management.

    Purpose of the Study:

    • To evaluate the efficacy of corinfarretard in patients with stage II-III left ventricular diastolic dysfunction.
    • To compare the effects of corinfarretard on disordered relaxation and restrictive type diastolic dysfunction.

    Main Methods:

    • A study involving 52 patients with stage II-III left ventricular diastolic dysfunction (disordered relaxation and restrictive types).
    • Patients received corinfarretard (10-20 mg daily) for an average of 19.4 days.
    • Echocardiography and doppleroechocardiography were performed before and after treatment.

    Main Results:

    • Corinfarretard treatment led to improvements in diastolic temporal patterns in patients with diastolic dysfunction.
    • Patients with disordered relaxation type diastolic dysfunction experienced the most significant benefits.
    • No significant changes in diastolic parameters were observed in patients with restrictive type diastolic dysfunction.

    Conclusions:

    • Corinfarretard demonstrates a beneficial effect on disordered relaxation type diastolic dysfunction.
    • The drug does not appear to significantly alter diastolic function in patients with restrictive type diastolic dysfunction.

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