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Related Experiment Videos

Quantification of blood flow.

D Cosgrove1, R Eckersley, M Blomley

  • 1Imperial College of Medicine, Hammersmith Hospital, London, UK. d.cosgrove@ic.ac.uk

European Radiology
|August 25, 2001
PubMed
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Microbubbles in ultrasound imaging offer advanced blood flow measurement beyond traditional Doppler methods. These contrast agents enable precise perfusion quantification by analyzing microbubble transit and refilling dynamics.

Area of Science:

  • Medical Imaging
  • Ultrasound Technology
  • Hemodynamics

Background:

  • Traditional Doppler ultrasound for blood flow estimation has limitations, including significant errors and accuracy issues.
  • Microbubbles, initially contrast agents, can also serve as tracers for blood flow analysis.
  • Existing methods struggle with attenuated signals or very slow flow, necessitating improved techniques.

Purpose of the Study:

  • To explore the utility of microbubbles as tracers for accurate blood flow and perfusion measurement.
  • To demonstrate how microbubble transit-time methods can overcome limitations of traditional Doppler ultrasound.
  • To introduce a novel method for quantifying tissue perfusion using microbubble dynamics.

Main Methods:

  • Utilizing microbubbles as tracers with transit-time methods, analyzing arterial and venous time-intensity data.

Related Experiment Videos

  • Acquiring tissue and feeding artery intensity curves to track microbubble transit.
  • Employing a "negative bolus" technique with high and low-intensity ultrasound beams to assess refilling dynamics.

    • Main Results:

    • Microbubble transit analysis can reveal hemodynamic alterations, such as liver arterialisation in malignancies and delayed transit in transplant kidneys.
    • The "negative bolus" method allows extraction of reperfusion rate (slope) and fractional vascular volume (asymptote).
    • The product of reperfusion rate and vascular volume provides a measure of true tissue perfusion.

    Conclusions:

    • Microbubbles offer a versatile tool for advanced hemodynamic assessment and accurate blood flow quantification.
    • The described microbubble techniques provide superior insights into tissue perfusion compared to traditional methods.
    • This approach has potential applications in diagnosing and monitoring various clinical conditions, including malignancies and transplant rejection.