Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vitamin E: action, metabolism and perspectives.

E Herrera1, C Barbas

  • 1Facultad de Ciencias Experimentales y Técnicas, Universidad San Pablo-CEU, Madrid, Spain. eherrera@ceu.es

Journal of Physiology and Biochemistry
|August 25, 2001
PubMed
Summary

Vitamin E, a key antioxidant, has complex roles beyond preventing free radical damage. Its transport and metabolism involve lipoproteins, with ongoing research into its interactions with other antioxidants for enhanced health benefits.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural elucidation of derivatives of polyfunctional metabolites after methyl chloroformate derivatization by high-resolution mass spectrometry gas chromatography. Application to microbiota metabolites.

Journal of chromatography. A·2024
Same author

Early Leishmania infectivity depends on miR-372/373/520d family-mediated reprogramming of polyamines metabolism in THP-1-derived macrophages.

Scientific reports·2024
Same author

Adipose tissue development and lipid metabolism in the human fetus: The 2020 perspective focusing on maternal diabetes and obesity.

Progress in lipid research·2020
Same author

5-Nitroimidazole refractory giardiasis is common in Matanzas, Cuba and effectively treated by secnidazole plus high-dose mebendazole or quinacrine: a prospective observational cohort study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2020
Same author

Acral Metastasis of the Fingers: Report of 2 Cases.

Actas dermo-sifiliograficas·2018
Same author

Supplementing sow diets with palm oil during late gestation and lactation: effects on milk production, sow hormonal profiles and growth and development of her offspring.

Animal : an international journal of animal bioscience·2018

Area of Science:

  • Biochemistry
  • Nutrition Science
  • Cell Biology

Background:

  • Natural vitamin E comprises tocopherols and tocotrienols, with RRR-alpha-tocopherol being the most biologically active form.
  • Vitamin E functions as the primary lipid-soluble antioxidant in the body, protecting cell membranes from free radical propagation.
  • Beyond its antioxidant role, vitamin E exhibits pro-oxidant activity and forms non-radical oxidation products excreted via bile or urine.

Purpose of the Study:

  • To elucidate the multifaceted roles and metabolism of vitamin E.
  • To explore the transport mechanisms of vitamin E through plasma lipoproteins.
  • To investigate the interactions of vitamin E with other antioxidants and their implications for health benefits.

Main Methods:

  • Review of existing literature on vitamin E's biochemical functions and metabolic pathways.

Related Experiment Videos

  • Analysis of vitamin E's absorption, transport via chylomicrons and lipoproteins (VLDL, IDL, LDL, HDL), and tissue uptake.
  • Examination of vitamin E's antioxidant and pro-oxidant activities and its excretion routes.

    • Main Results:

    • Vitamin E absorption involves packaging into chylomicrons, with subsequent uptake by extrahepatic tissues and the liver.
    • The liver plays a crucial role in vitamin E metabolism via the alpha-tocopherol transfer protein, incorporating it into VLDL.
    • Vitamin E delivery to tissues occurs through lipoprotein uptake, with ongoing questions regarding its synergistic effects with other antioxidants.

    Conclusions:

    • Vitamin E's biological activity extends beyond simple antioxidant function, involving complex metabolic and transport pathways.
    • Understanding vitamin E's interaction with other antioxidants is key to explaining the enhanced benefits observed from whole foods.
    • Further research is needed to fully unravel the intricate mechanisms of vitamin E action and its synergistic effects.