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Hypercalciuria in ex-preterm children, aged 7-8 years.

C A Jones1, L S Bowden, R Watling

  • 1Institute of Child Health, Alder Hey, Liverpool, UK. CAJones@doctors.org.uk

Pediatric Nephrology (Berlin, Germany)
|August 25, 2001
PubMed
Summary

Preterm children exhibit higher urinary calcium excretion and lower bone mineral density (BMD). This increased calcium excretion is linked to neonatal aminoglycoside exposure and reduced hip BMD in preterm individuals.

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Area of Science:

  • Pediatrics
  • Nephrology
  • Bone Metabolism

Background:

  • Previous studies indicated elevated urinary calcium in ex-preterm infants.
  • This study aimed to confirm findings and explore the link between calcium excretion and bone mineralization.

Purpose of the Study:

  • To confirm increased urinary calcium excretion in ex-preterm children.
  • To determine if elevated urinary calcium is associated with reduced bone mineral density (BMD).
  • To investigate the relationship between neonatal aminoglycoside levels and urinary calcium excretion.

Main Methods:

  • Recruited 46 ex-preterm children (7-9 years) and 40 controls.
  • Collected 3 separate 24-hour urine samples for calcium analysis.
  • Utilized dual-energy X-ray absorptiometry (DXA) to measure bone mineral content and BMD.

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Main Results:

  • Ex-preterm children showed significantly higher 24-hour urinary calcium than controls (P=0.01).
  • Increased calcium excretion correlated with higher neonatal aminoglycoside levels (P=0.0013).
  • Preterm children with hypercalciuria had lower height and hip BMD compared to controls (P=0.04, P=0.004).

Conclusions:

  • Preterm children exhibit higher urinary calcium excretion and are shorter with lower hip BMD.
  • Hypercalciuria in preterm children is linked to neonatal aminoglycoside exposure and impaired bone mineralization.
  • Further research is needed to assess the long-term risks of impaired bone mineralization in preterm individuals.