Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunologic tolerance.

A M Krensky1

  • 1Department of Pediatrics, Stanford University, CA 94305-5164, USA. krensky@stanford.edu

Pediatric Nephrology (Berlin, Germany)
|August 25, 2001
PubMed
Summary
This summary is machine-generated.

Achieving immunologic tolerance, a state of antigen-specific non-responsiveness, is crucial for treating autoimmune diseases and improving transplant acceptance. Advances in mixed chimerism and costimulatory blockade pave the way for clinical applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

KLF13 regulates the differentiation-dependent human papillomavirus life cycle in keratinocytes through STAT5 and IL-8.

Oncogene·2016
Same author

Biology and clinical relevance of granulysin.

Tissue antigens·2009
Same author

Visiting a forest, but not a city, increases human natural killer activity and expression of anti-cancer proteins.

International journal of immunopathology and pharmacology·2008
Same author

Forest bathing enhances human natural killer activity and expression of anti-cancer proteins.

International journal of immunopathology and pharmacology·2007
Same author

Chemokines and allograft rejection: narrowing the list of suspects.

Transplantation·2001
Same author

Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vgamma9/Vdelta2 T lymphocytes.

The Journal of infectious diseases·2001
Same journal

Correlation between urinary soluble CD163 and endocapillary proliferation and fibrinoid necrosis in IgA vasculitis with nephritis.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

SGLT2i, anti-endothelin A and double endothelin and angiotensin inhibitors: a new future for chronic kidney disease in children.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

The role of urinary trehalase levels in the early diagnosis of acute kidney injury in dehydrated children.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Neuron-specific enolase and brain-derived neurotrophic factor as developmental neurovascular markers in chronic kidney disease and kidney transplantation.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Chronic hyponatraemia with a reset osmostat: when abnormal is normal.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Clinical value of repeat kidney biopsy in pediatric IgA vasculitis nephritis.

Pediatric nephrology (Berlin, Germany)·2026
See all related articles

Area of Science:

  • Immunology
  • Transplantation Science
  • Autoimmune Disease Research

Background:

  • Immunologic tolerance is key to understanding autoimmune diseases and transplant acceptance.
  • Recent preclinical models show promise for clinical applications.

Purpose of the Study:

  • To review historical perspectives and recent progress in inducing and maintaining immunologic tolerance.
  • Focus on applications relevant to pediatric nephrology.

Main Methods:

  • Review of basic studies and preclinical models.
  • Exploration of mixed chimerism, costimulatory blockade, immune deviation, and HLA-derived peptides.
  • Mention of the Immune Tolerance Network's clinical trial development.

Main Results:

Related Experiment Videos

  • Progress in preclinical models suggests clinical applications are now feasible.
  • The Immune Tolerance Network is actively developing clinical trials.

Conclusions:

  • Advances in immunologic tolerance induction and maintenance are significant.
  • These developments hold promise for pediatric nephrology, autoimmune diseases, and transplantation.