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Related Experiment Videos

Microchip capillary electrophoresis/electrochemistry.

N A Lacher1, K E Garrison, R S Martin

  • 1Department of Pharmaceutical Chemistry, University of Kansas, Lawrence 66047, USA.

Electrophoresis
|August 25, 2001
PubMed
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Microchip capillary electrophoresis (CE) with electrochemical (EC) detection integrates multiple analytical steps onto a single device. This review highlights advancements and applications of miniaturized CE-EC systems for diverse analyses.

Area of Science:

  • Analytical Chemistry
  • Microfluidics
  • Electrochemistry

Background:

  • Microfabricated fluidic devices enable integrated sample preparation, separation, and detection.
  • Microchip capillary electrophoresis (CE) offers miniaturized analytical capabilities.
  • Electrochemical (EC) detection provides sensitivity and selectivity for microchip systems.

Purpose of the Study:

  • To review progress in microchip CE coupled with EC detection.
  • To describe essential components and detector configurations for microchip CE-EC.
  • To detail applications of this integrated technique.

Main Methods:

  • Review of microfabricated analytical systems.
  • Focus on microchip capillary electrophoresis (CE).

Related Experiment Videos

  • Integration with electrochemical (EC) detection.

    • Main Results:

    • Demonstration of integrated analytical processes on a microchip.
    • Description of various detector configurations for microchip CE-EC.
    • Successful application to diverse analytes including catechols, amino acids, and PCR products.

    Conclusions:

    • Microchip CE-EC systems offer a powerful platform for miniaturized analysis.
    • The technique is versatile, applicable to a wide range of chemical and biological samples.
    • Advancements in microfabrication and detection enhance analytical performance.