Potential central nervous system antineoplastic agents. Amides of 6-cyano-6-norlysergic acid

A group of amides of 6-cyano-6-norlysergic acid was prepared from their corresponding lysergamides. None of these N-cyano derivatives showed anticancer activity against lymphoid leukemia L1210 in mice. This is in contrast to the reported in vitro anticancer activity (P-815 mastocytoma) of 6-cyano-6-norlysergic acid diethylamide.