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LL-Z1271alpha: an interleukin-1beta production inhibitor
K Ichikawa1, T Inagaki, H Kachi-Tonai
1Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc., 5-Gochi Taketoyo-cho, Chita-gun, Aichi 470-2393, Japan. katsuomi ichikawa@japan.pfizer.com
Abstract:
LL-Z1271alpha, a fungal metabolite, dose-dependently inhibited interleukin-1beta (IL-1beta) production in lipopolysaccharide (LPS)-stimulated human whole blood. Oral administration of LL-Z1271alpha to LPS-challenged mice caused significant lowering in the IL-1beta levels in peritoneal cavity. Data presented suggest that LL-Z1271alpha inhibits IL-1beta production by a novel mechanism as the inhibitory activity was not due to effects on caspase-1 (IL-1beta converting enzyme), the ATP-induced release mechanism or a lysosomotrophic effect.