Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interleukin-2 activates human peripheral blood eosinophils.

R Hoenstein1, D Admon, A Solomon

  • 1Department of Pharmacology, Hadassah University Hospital and The Hebrew University, Jerusalem, 91120, Israel.

Cellular Immunology
|August 25, 2001
PubMed
Summary

Interleukin-2 (IL-2) activates eosinophils to release mediators like eosinophil peroxidase (EPO) and IL-6. This suggests IL-2 plays a role in allergic inflammation and is a potential drug target.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association Between Negative Pregnancy Desires and Recent Condomless Sex Among Couples in Vietnam.

Journal of sex research·2025
Same author

Energetic Electron Precipitation Driven by Electromagnetic Ion Cyclotron Waves from ELFIN's Low Altitude Perspective.

Space science reviews·2023
Same author

The ELFIN Mission.

Space science reviews·2020
Same author

Optical fiber sensors for monitoring in critical care.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2020
Same author

Is Plan A OK in the 'plausibly difficult' airway?

Anaesthesia·2017
Same author

Credibility, integrity, transparency & courage: The Haitian Cholera outbreak and the United Nations (UN).

Journal of infection and public health·2017

Area of Science:

  • Immunology
  • Allergy and Inflammation Research

Background:

  • Eosinophils are key cells in allergic inflammation.
  • Interleukin-2 (IL-2) is a cytokine involved in immune responses.

Purpose of the Study:

  • To investigate the in vitro effects of IL-2 on human eosinophil survival and mediator release.
  • To explore IL-2's role in allergic inflammation and its potential as a therapeutic target.

Main Methods:

  • Isolated and purified human peripheral blood eosinophils from atopic donors.
  • Cultured eosinophils with IL-2, interferon-gamma (IFN-γ), and granulocyte-macrophage colony-stimulating factor (GM-CSF).
  • Measured eosinophil peroxidase (EPO) and IL-6 release, and evaluated cell viability.

Main Results:

Related Experiment Videos

  • IL-2, IFN-γ, and GM-CSF significantly increased eosinophil EPO release.
  • IL-2 and IFN-γ induced significant IL-6 release from eosinophils.
  • Nedocromil sodium inhibited IL-2-induced EPO release.

Conclusions:

  • IL-2 activates peripheral blood eosinophils, promoting the release of granule mediators (EPO) and cytokines (IL-6).
  • The presence of IL-2 receptors on eosinophils supports these findings.
  • IL-2 is implicated as a significant mediator in allergic inflammation and a potential target for pharmacological intervention.