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Malignant struma ovarii with thyrotoxicosis
K Matsuda1, T Maehama, K Kanazawa
1Department of Obstetrics and Gynecology, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Gynecologic Oncology
|August 25, 2001
Summary
Malignant struma ovarii, a rare ovarian tumor, can be diagnosed before surgery. This case highlights the importance of considering thyrotoxicosis in ovarian cancer evaluations.
Area of Science:
- Gynecologic Oncology
- Endocrinology
- Pathology
Background:
- Malignant struma ovarii is a rare ovarian neoplasm.
- Preoperative diagnosis is challenging due to disease rarity and thyrotoxicosis complications.
Observation:
- A 48-year-old woman presented with hyperthyroidism symptoms and a pelvic mass.
- Elevated thyroid function tests were noted despite a normal-appearing thyroid gland.
Findings:
- Preoperative diagnosis of hormone-producing malignant struma ovarii was established.
- Surgical findings confirmed FIGO stage Ia ovarian papillary adenocarcinoma of the thyroid.
- Positive thyroglobulin immunohistochemistry and high ovarian venous thyroglobulin levels were observed.
Implications:
- Malignant struma ovarii is diagnosable preoperatively.
- Thyrotoxicosis should be considered in the differential diagnosis of ovarian tumors.