Related Experiment Video

Updated: Jul 28, 2026

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
07:07

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Published on: February 21, 2016

Distribution of immunophilin FKBP-12 protein and mRNA within the mammalian cochlea and cochlear nucleus

G Zajic1, C Henley, J C Louis

  • 1Department of Neuroscience, Amgen Inc, Thousand Oaks, CA 91320-1789, USA. gzajic@amgen.com

Hearing Research
|August 25, 2001
PubMed

Immunophilin FK binding protein-12 (FKBP-12), the soluble receptor for the immunosuppressant drug FK506, is involved in a number of neuronal activities including increased nerve regeneration in the peripheral nervous system and enhanced recovery in animal models of neurodegenerative diseases. In addition, FKBP-12 is tightly bound to the calcium release channel ryanodine receptor and physiologically interacts with the inositol 1,4,5-trisphosphate receptor. In nearly all cell types, release of intracellular Ca(2+) and subsequent second messenger signaling involves activation of these ion channels. We determined the distribution of FKBP-12 within the mammalian cochlea and dorsal cochlear nucleus (DCN) in order to gain insight into Ca(2+) regulation within the cochlea and to possibly identify potential cellular targets for neuroimmunophilin ligands that may prove useful in protection and recovery following ototoxic insult. FKBP-12 protein and mRNA were found to be abundant throughout rat and guinea pig cochlea and DCN.

More Related Videos

Whole Mount Dissection and Immunofluorescence of the Adult Mouse Cochlea12:02

Whole Mount Dissection and Immunofluorescence of the Adult Mouse Cochlea

Published on: January 1, 2016

Immunolabeling and Counting Ribbon Synapses in Young Adult and Aged Gerbil Cochleae08:25

Immunolabeling and Counting Ribbon Synapses in Young Adult and Aged Gerbil Cochleae

Published on: April 21, 2022

Related Concept Videos

Hair Cells01:22

Hair Cells

Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
The Cochlea01:13

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.