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Alterations in hypothalamic function following thermal injury.

D W Wilmore, T W Orcutt, A D Mason

    The Journal of Trauma
    |August 11, 1975
    PubMed
    Summary
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    Burn patients exhibit altered thermoregulation and hormonal responses, seeking higher comfort temperatures and showing abnormal glucose and human growth hormone (HGH) levels. These metabolic changes suggest hypothalamic readjustment after thermal trauma.

    Area of Science:

    • Physiology
    • Endocrinology
    • Thermoregulation

    Background:

    • Severe burns disrupt normal physiological functions, including thermoregulation and hormonal balance.
    • Understanding metabolic alterations post-thermal trauma is crucial for patient recovery and management.

    Purpose of the Study:

    • To investigate alterations in comfort temperature regulation and human growth hormone (HGH) secretion in burn patients.
    • To explore the relationship between fasting hyperglycemia, HGH response, and hypothalamic function after thermal injury.

    Main Methods:

    • Assessed optimal comfort temperature selection in burn patients and healthy controls within an environmental chamber.
    • Measured fasting and stimulated HGH levels (via insulin hypoglycemia and arginine infusion) in burn patients and controls.

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  • Monitored core and skin temperatures, fasting blood glucose, and HGH response to stimuli.

    • Main Results:

    • Burn patients selected significantly higher comfort temperatures and exhibited elevated core and surface temperatures compared to controls.
    • Fasting HGH levels were significantly elevated in burn patients, despite fasting hyperglycemia.
    • HGH response to insulin hypoglycemia and arginine infusion was diminished in burn patients, returning towards normal with recovery.

    Conclusions:

    • Thermal trauma induces significant alterations in thermoregulation, glucose metabolism, and HGH secretion.
    • These metabolic and hormonal changes suggest a homeostatic readjustment within the hypothalamus following severe burns.
    • The findings highlight the complex physiological responses to thermal injury and their potential impact on recovery.