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MD-2 binds to bacterial lipopolysaccharide
S Viriyakosol1, T Kirkland, K Soldau
1Department of Pathology and Medicine, Department of Veterans Affairs Medical Center, University of California San Diego, USA.
Journal of Endotoxin Research
|August 25, 2001
Abstract:
Many LPS binding proteins have been described, but the exact nature of the LPS receptors that signal cells remains unclear. MD-2 is a molecule that is found in association with Toll-like receptor 4, which has been shown to be a receptor for LPS. We have produced human MD-2 in baculovirus and tested it for LPS binding. MD-2 binds the lipid A region of LPS without the need for LPS binding protein. These data suggest that MD-2 may be binding LPS as part of the TLR4 receptor complex.