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Updated: Aug 17, 2026

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)
Published on: November 20, 2016
Orbital presentations of giant cell arteritis
A G Lee1, R A Tang, S E Feldon
1Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City 52242, USA. Andrew-lee@uiowa.edu
Background:
giant cell arteritis (GCA) is a systemic vasculitis that may affect the optic nerve and cause blindness (e.g. ischemic optic neuropathy). Orbital inflammatory disease, however, is an uncommon presentation of GCA.
Purpose:
to alert clinicians to the orbital presentations of GCA.
Patients And Methods:
a retrospective case series from tertiary care academic ophthalmic referral centers of four patients with orbital manifestations of giant cell arteritis.
Results:
presentation of cases and review of the literature. In three cases, a temporal artery biopsy was diagnostic of GCA, but in one case, an orbital biopsy was needed to confirm the diagnosis.
Conclusion:
GCA can have orbital manifestations and clinicians should be aware of this unusual presentation of GCA in cases of presumed orbital inflammatory pseudotumor in the elderly.
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