Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thalamic activation during an attention-to-prepulse startle modification paradigm: a functional MRI study.

E A Hazlett1, M S Buchsbaum, C Y Tang

  • 1Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA.

Biological Psychiatry
|August 28, 2001
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

d-Wave Fermi Surface Instability in the Nematic Phase of Two Monolayer FeSe/SrTiO<sub>3</sub>.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

[Successful treatment of Bouveret syndrome by endoscopic titanium laser: a case report].

Zhonghua nei ke za zhi·2022
Same author

[Clinical characteristics analysis of two cases of nosebleed with acute cerebral hemorrhage].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2021
Same author

[Investigation and retrospective analysis of a family of Lynch syndrome].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2019
Same author

Severe childhood trauma and clinical and neurocognitive features in schizotypal personality disorder.

Acta psychiatrica Scandinavica·2019
Same author

Water transport properties of boron nitride nanosheets mixed matrix membranes for humic acid removal.

Heliyon·2019

This study used fMRI to show that the thalamus is involved in modulating prepulse inhibition (PPI) of the startle reflex when attention is directed. These findings in humans align with animal models of brain circuitry.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Prepulse inhibition (PPI) of the startle reflex is a measure of early information processing.
  • Selective attention modulates PPI, with medial frontal-thalamic circuitry implicated in animal models.
  • Previous research lacked human functional neuroimaging data on attention's effect on PPI circuitry.

Purpose of the Study:

  • To investigate differential brain activation within the medial frontal-thalamic circuitry during attended versus ignored prepulse inhibition (PPI) using fMRI.
  • To examine the role of attention in modulating brain responses related to PPI.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was performed on ten healthy subjects.
  • Subjects listened to attended and ignored tones as prepulses to a startle stimulus during fMRI.

Related Experiment Videos

  • Regions of interest were identified on structural MRI and coregistered to fMRI data.

    • Main Results:

    • The right thalamus, including anterior and mediodorsal nuclei, showed greater fMRI response to attended PPI than ignored PPI.
    • The startle-alone condition resulted in deactivation in these thalamic regions.
    • The transitional medial cortex (Brodmann Area 32) exhibited varied responses based on attention and stimulus conditions.

    Conclusions:

    • Findings support the involvement of the thalamus in modulating PPI in humans, extending previous animal model research.
    • This study provides a foundation for further fMRI investigations into the neural circuitry of PPI modulation.
    • Understanding these mechanisms is crucial for studying normal and disordered PPI modulation.