Analytical evaluation of the Bio-Rad variant II automated HbA(1C) analyzer
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T N Higgins1, G B Blakney, J Dayton
1Dynacare Kasper Medical Laboratories, T5V 1B4, Edmonton, Alberta, Canada. Higgins@dkml.com
Objectives:
To evaluate the analytical performance of the Bio-Rad Variant II HbA(1C) analyzer (a completely automated system for the quantification of glycohemoglobin [HbA(1C)] in blood).
Design And Methods:
The analytical parameters of precision, linearity and analytical range were assessed and HbA(1C) results from the Variant II were compared to HbA(1C) results from the Bio-Rad Variant (a method certified by the National Glycohemoglobin Standardization Program). The effect of a variety of hemoglobin variants on HbA(1C) obtained on the system was investigated.
Results:
Total imprecision was less than 5% and the results compared well with those from an established method. The method has a wide analytical range with no carryover between specimens.
Conclusion:
The HbA(1C) method on the Variant II gives acceptable analytical performance.
