Related Experiment Videos
Synthesis and biological evaluation of novel daunorubicin-estrogen conjugates
K M Kasiotis1, P Magiatis, H Pratsinis
1Chemistry Lab., Agric. University of Athens, Iera odos 75, 11855, Athens, Greece.
Steroids
|August 28, 2001
Abstract:
The synthesis of two novel daunorubicin-estrogen conjugates with a steroidal and a non-steroidal ligand was undertaken in an attempt to target the cytotoxicity of anthracycline to estrogen-receptor positive cells. These conjugates (3 and 4), in contrast to their corresponding ligands, displayed weak binding affinities of 0.079 and 0.851 for the estrogen receptor. Conjugate 3 was consistently more cytotoxic than 4, which however showed some selectivity to estrogen receptor positive cell lines.