Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nicotine and tobacco dependence: normalization or stimulation?

E F Domino1

  • 1Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-0632, USA. efdabcde@umich.edu

Alcohol (Fayetteville, N.Y.)
|August 28, 2001
PubMed
Summary

Tobacco smoking normalizes brain activity in deprived smokers, increasing dominant alpha rhythm. Acute smoking further stimulates brain activity, as shown by electroencephalographic studies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chemical dissociation of human awareness: focus on non-competitive NMDA receptor antagonists.

Journal of psychopharmacology (Oxford, England)·2012
Same author

The differential effects of plasma from two groups of clinically similar schizophrenic patients on learning behavior in rats.

Journal of psychiatric research·2009
Same author

Tobacco smoking and MRI/MRS brain abnormalities compared to nonsmokers.

Progress in neuro-psychopharmacology & biological psychiatry·2008
Same author

Allergic reactions to isosulfan blue during sentinel node biopsy--a common event.

Surgery·2001
Same author

Regional cerebral blood flow effects of nicotine in overnight abstinent smokers.

Biological psychiatry·2001
Same author

Nicotine induced behavioral locomotor sensitization.

Progress in neuro-psychopharmacology & biological psychiatry·2001

Area of Science:

  • Neuroscience
  • Psychopharmacology

Background:

  • Nicotine and tobacco use exert complex stimulant and depressant effects on brain function.
  • Electroencephalographic (EEG) studies have investigated the impact of smoking on brain activity patterns.

Purpose of the Study:

  • To examine the effects of tobacco deprivation and acute smoking on dominant alpha rhythm in smokers.
  • To determine if tobacco smoking normalizes or stimulates brain activity.

Main Methods:

  • Electroencephalographic (EEG) recordings were used to measure dominant alpha rhythm.
  • Studies involved tobacco smokers undergoing periods of deprivation and acute smoking.

Main Results:

  • Tobacco deprivation (10-24 h) led to decreased dominant alpha rhythm in some smokers.
  • Immediate smoking normalized alpha rhythm to levels observed in nonsmokers.
  • Acute smoking increased dominant alpha rhythm beyond that of nonsmokers, indicating stimulation.

Conclusions:

  • Tobacco smoking appears to normalize brain activity in deprived smokers.
  • Acute tobacco smoking acts as a stimulant to brain activity in smokers.

Related Experiment Videos