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Updated: Oct 4, 2026

Production of Double-stranded DNA Ministrings
Published on: February 29, 2016
Delivery systems for DNA-binding drugs as gene expression modulators
1Dipartimento di Scienze Farmaceutiche, via Fossato di Mortara 19, 44100, Tel.: +39 0532 291259; fax: +39 0532 291296, Ferrara, Italy
Abstract:
Despite the large number of publications describing the synthesis and physicocharacterization of the binding between drugs and DNA, relatively few examine drug delivery systems (DDSs) for these molecules. The aim to find DDSs for DNA-binding drugs (DBDs) was prompted mainly to reduce the toxicity and/or enhance the tumor specificity of systemically administered drugs. With this in mind, we have reviewed the biological effects of some DBDs that are currently used as antitumor drugs and describe a brief selection of DDSs currently in clinical trials or on the market.
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What is Gene Expression?
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...

