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Related Experiment Videos

Delivery systems for DNA-binding drugs as gene expression modulators.

R Cortesi1, C Nastruzzi

  • 1Dipartimento di Scienze Farmaceutiche, via Fossato di Mortara 19, 44100, Tel.: +39 0532 291259; fax: +39 0532 291296, Ferrara, Italy

Drug Discovery Today
|August 28, 2001
PubMed
Summary

Researchers reviewed drug delivery systems (DDSs) for DNA-binding drugs (DBDs). The goal is to reduce toxicity and improve tumor targeting for these potent anticancer agents.

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Area of Science:

  • Pharmacology and Drug Delivery
  • Molecular Biology and Genetics

Background:

  • Extensive research exists on DNA-binding drugs (DBDs) synthesis and characterization.
  • Limited studies focus on developing drug delivery systems (DDSs) for these molecules.

Purpose of the Study:

  • To review the biological effects of established antitumor DBDs.
  • To present a selection of DDSs for DBDs in clinical trials or on the market.
  • To address the need for reduced toxicity and enhanced tumor specificity of systemically administered DBDs.

Main Methods:

  • Literature review of biological effects of selected DBDs.
  • Survey of current drug delivery systems (DDSs) for DNA-binding drugs (DBDs).

Main Results:

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  • Identified several DNA-binding drugs (DBDs) with significant antitumor activity.
  • Highlighted various drug delivery systems (DDSs) being investigated or utilized for DBDs.

    • Conclusions:

    • Drug delivery systems (DDSs) show promise for improving the therapeutic index of DNA-binding drugs (DBDs).
    • Further development of DDSs is crucial for enhancing tumor specificity and reducing systemic toxicity of DBDs.