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Inverse association between trans isomeric and long-chain polyunsaturated fatty acids in cord blood lipids of

T Decsi1, I Burus, S Molnár

  • 1Department of Paediatrics, University of Pécs, Pécs, Hungary. decsi@apacs.pote.hu

The American Journal of Clinical Nutrition
|August 28, 2001
PubMed

Insights

Maternal trans fatty acid intake inversely affects essential fatty acid levels in full-term infants. This study highlights a potential link between maternal diet and infant lipid profiles at birth.

Area of Science:

  • Nutritional science
  • Pediatric nutrition
  • Biochemistry

Background:

  • Previous research indicated inverse correlations between trans fatty acids and polyunsaturated fatty acids in preterm infants and children.
  • The significance of these correlations in full-term infants at birth was previously unevaluated.

Purpose of the Study:

  • To investigate the relationship between trans fatty acids and long-chain polyunsaturated fatty acids in full-term infants at birth.
  • To assess maternal dietary influence on infant lipid profiles.

Main Methods:

  • Studied 42 healthy full-term infants born after normal pregnancies.
  • Analyzed fatty acid composition in venous cord blood lipids using high-resolution capillary gas-liquid chromatography.
  • Infants included had a family history of atopy.

Main Results:

  • Significant inverse correlations were found between trans fatty acids and arachidonic acid/docosahexaenoic acid.
  • These correlations were observed in phospholipids, cholesterol esters, and nonesterified fatty acids.
  • Specific correlation coefficients (r) and p-values were reported for each lipid fraction.

Conclusions:

  • Trans fatty acids in fetal circulation likely originate from maternal diet.
  • Maternal trans fatty acid exposure may be a critical factor influencing infant long-chain polyunsaturated fatty acid status.
  • This highlights a potentially overlooked dietary variable affecting neonatal lipid composition.
Abstract

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