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Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal

S V Walsh1, A M Hopkins, J Chen

  • 1Epithelial Pathobiology Research Unit, Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

Gastroenterology
|August 28, 2001
PubMed
Summary

Rho kinase (ROCK) regulates intestinal epithelial barrier function by organizing the actin cytoskeleton and is essential for forming tight junctions. Inhibition disrupts barrier integrity and junction assembly.

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