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Related Experiment Videos

Perceived stress and cellular immunity: when coping counts.

J R Stowell1, J K Kiecolt-Glaser, R Glaser

  • 1Department of Psychiatry, Ohio State University, USA. jrstowell@eiu.edu

Journal of Behavioral Medicine
|August 29, 2001
PubMed
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Active coping enhances immune response under high stress, while avoidance coping benefits immune function during low stress in older adults. Coping strategies interact with stress levels to influence immune cell activity.

Area of Science:

  • Psychoneuroimmunology
  • Gerontology
  • Immunology

Background:

  • Stress significantly impacts immune function.
  • Coping strategies are psychological responses to stress.
  • The interplay between stress, coping, and immunity in older adults requires further investigation.

Purpose of the Study:

  • To examine the differential relationships between active and avoidance coping strategies and immune function.
  • To investigate whether these relationships are moderated by perceived stress levels.
  • To assess immune cell counts and T-lymphocyte proliferative responses in healthy older adults.

Main Methods:

  • Cross-sectional study design.
  • Assessment of perceived stress and coping methods in 173 healthy older adults.

Related Experiment Videos

  • Measurement of CD3+, CD4+, and CD8+ T lymphocyte counts and percentages.
  • Evaluation of peripheral blood leukocyte proliferative responses to phytohemagglutinin (PHA) and concanavalin A (Con A).

    • Main Results:

    • Both active and avoidance coping significantly interacted with perceived stress to affect mitogen-induced proliferative responses.
    • Higher active coping was associated with a more robust T-lymphocyte proliferative response, particularly under high stress conditions.
    • At low stress levels, active coping showed no significant association with proliferative responses, whereas avoidance coping was linked to a greater response to Con A.

    Conclusions:

    • The relationship between coping strategies and immune function is contingent upon the individual's perceived stress level.
    • Active coping may bolster immune responses during heightened stress, while avoidance coping might be beneficial under lower stress conditions.
    • These findings highlight the complex interplay between psychological factors and immune regulation in aging.