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Factor V Leiden: a clinical review.

¹University of Texas Southwestern Medical School, Dallas 75390-8889, USA. ray.lee@utsouthwestern.edu

The American Journal of the Medical Sciences

|August 29, 2001

Summary

Factor V Leiden is a common genetic thrombophilia. While linked to venous clots, its role in other conditions requires further investigation.

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Area of Science:

Hematology
Genetics
Thrombosis

Background:

Factor V Leiden is the most common inherited thrombophilia.
It is prevalent in individuals of European descent.
Its association with venous thromboembolism is well-established.

Purpose of the Study:

To review the current literature on Factor V Leiden.
To discuss its prevalence, mechanisms, and clinical associations.
To explore its role in various disease states beyond venous thromboembolism.

Main Methods:

Literature review of scientific articles and clinical data.
Analysis of genetic and functional diagnostic methods.
Examination of screening, treatment, and clinical implications.

Main Results:

Factor V Leiden is strongly associated with venous thromboembolism.
Its role in arterial thrombosis and pregnancy complications is less clear.
Diagnostic approaches and treatment strategies are evolving.

Conclusions:

Factor V Leiden is a significant risk factor for venous thromboembolism.
Further research is needed to clarify its role in other thrombotic conditions.
Comprehensive understanding aids in risk assessment and management.

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