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Related Experiment Videos

How do kinins affect vascular tone?

U S Ryan, J W Ryan, C Whitaker

    Advances in Experimental Medicine and Biology
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Kinins influence vascular tone indirectly. Specialized cell junctions between endothelial and smooth muscle cells allow kinins to affect muscle tone without direct interaction, challenging previous assumptions.

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    Area of Science:

    • Vascular Biology
    • Cellular Physiology
    • Pharmacology

    Background:

    • Kinins are known to affect vascular tone.
    • It is widely assumed that kinins act directly on vascular smooth muscle cells.
    • The endothelium presents a barrier to direct kinin-smooth muscle interaction.

    Purpose of the Study:

    • To investigate the mechanism by which kinins affect vascular smooth muscle tone.
    • To determine if kinins act directly on smooth muscle or through endothelial cells.
    • To explore the role of specialized cell contacts in mediating kinin effects.

    Main Methods:

    • Review of existing literature on kinin-endothelial-smooth muscle interactions.
    • Morphological analysis of pulmonary arterioles to identify cell contacts.

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  • Hypothetical modeling of kinin transport across the endothelium.

    • Main Results:

    • Endothelial cells possess mechanisms to hydrolyze kinins, limiting direct access to smooth muscle.
    • Specialized myoendothelial junctions and direct cell attachments exist between endothelial and smooth muscle cells.
    • Morphological evidence suggests indirect signaling pathways are plausible.

    Conclusions:

    • Kinins likely do not act directly on vascular smooth muscle.
    • Specialized cell junctions provide a basis for indirect kinin signaling to smooth muscle.
    • Endothelial cells play a crucial role in mediating the effects of kinins on vascular tone.