Related Experiment Videos
Small atypical leiomyomas: report of two cases
J Scurry1, P Kerdemelidis, D Fortune
1Mercy Pathology, Mercy Hospital for Women, Melbourne, Victoria, Australia. jscurry@mercy.com.au
Pathology
|August 29, 2001
Summary
Atypical uterine leiomyomas, though rare, can develop independently or within existing fibroids. These small lesions showed no recurrence after 60 months.
Area of Science:
- Gynecologic pathology
- Uterine oncology
Background:
- Uterine leiomyomas are common benign tumors.
- Atypical leiomyomas represent a less common subtype with specific histological features.
- Understanding their origin is crucial for accurate diagnosis and management.
Observation:
- Two cases of small atypical uterine leiomyomas were identified.
- Case 1: A 6-mm de novo lesion in a 53-year-old woman.
- Case 2: A 3-mm focus within a 12-mm leiomyoma in a 45-year-old woman.
Findings:
- Both lesions exhibited moderate atypia and a mitotic rate of 6/10 HPF.
- Absence of coagulative necrosis was noted in both cases.
- No exogenous hormone use was reported in either patient.
Implications:
- Atypical uterine leiomyomas can arise de novo or as part of a pre-existing leiomyoma.
- Long-term follow-up showed no recurrence or metastasis, suggesting a favorable prognosis for these small lesions.
- These findings contribute to the understanding of uterine leiomyoma heterogeneity and behavior.