Interactions between cadmium and zinc in the organism

It is well known that many toxic effects of cadmium (Cd) action result from interactions with essential elements, including zinc (Zn). These interactions can take place at different stages of absorption, distribution in the organism and excretion of both metals and at the stage of Zn biological functions. Exposure to Cd leads to disturbance in Zn in the organism on the one hand, while dietary Zn intake has an important effect on Cd absorption, accumulation and toxicity on the other. The Zn status of the body is important in relation to development of Cd toxicity. Numerous data show that increased Zn supply may reduce Cd absorption and accumulation and prevent or reduce the adverse actions of Cd, whereas Zn deficiency can intensify Cd accumulation and toxicity. In this review, the interactions between these two trace elements in humans and animals are discussed on the basis of the available literature and our own results, against the background of general population exposure to Cd and common nutritional deficiency of Zn.