Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Xenon does not affect human platelet function in vitro.

L W de Rossi1, N A Horn, J H Baumert

  • 1Department of Anesthesiology, University Hospital, Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany. L.derossi@gmx.de

Anesthesia and Analgesia
|August 29, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Telemedical anesthesia consent - Are the patients ready for it? : A comparative requirement analysis before and during the pandemic].

Die Anaesthesiologie·2024
Same author

Anaesthetic efficacy and postinduction hypotension with remimazolam compared with propofol: a multicentre randomised controlled trial.

Anaesthesia·2024
Same author

[Resuscitation of children with persistent ventricular fibrillation-A case for a mechanical resuscitation device?]

Die Anaesthesiologie·2023
Same author

[When emergency physician and tele-emergency physician save life together : A case description on the application of prehospital telemedicine for ventricular tachycardia with hemodynamic instability].

Der Anaesthesist·2021
Same author

[Appropriate allocation of resources for interhospital transfer in emergency medical service-is a physician in the dispatch center helpful?]

Der Anaesthesist·2020
Same author

[Implementation of anesthesia quality indicators in Germany : A prospective, national, multicenter quality improvement study].

Der Anaesthesist·2020
Same journal

Incomplete Recovery of Diaphragmatic Mechanics at a Train-of-Four Ratio of 0.90 to <0.95 Assessed by Dynamic Digital Radiography: A Proof-of-Concept Case Series.

Anesthesia and analgesia·2026
Same journal

Patients' Perspectives and Experiences of Participating in Anesthesia Research: A Qualitative Study.

Anesthesia and analgesia·2026
Same journal

Impact of Epidural-Related Maternal Fever on Neonatal Outcomes: A Single-Center Retrospective Case-Control Study Excluding Confirmed Histological Chorioamnionitis.

Anesthesia and analgesia·2026
Same journal

Patient Beliefs and Experiences of Adhering to Medical Therapies for Cardiovascular Comorbidities, Before Noncardiac Elective Surgery in South Africa: A Mixed-Methods Study.

Anesthesia and analgesia·2026
Same journal

Beyond Administrative Indices: Allostatic Load and Autonomic Dyshomeostasis as Biological Mediators of Intraoperative Cardiac Arrest.

Anesthesia and analgesia·2026
Same journal

In Response.

Anesthesia and analgesia·2026
See all related articles

Xenon gas does not impact platelet glycoprotein expression or hemostasis in vitro. This study found no significant effects of xenon on platelet function or blood clotting mechanisms, unlike halothane.

Area of Science:

  • Anesthesiology
  • Hematology
  • Biochemistry

Background:

  • Platelet function is crucial for hemostasis.
  • Noble gases like xenon are used in anesthesia.
  • Potential effects of xenon on platelet activity require investigation.

Purpose of the Study:

  • To investigate the in vitro effects of xenon on platelet glycoprotein expression.
  • To determine xenon's impact on platelet-related hemostasis under shear stress.

Main Methods:

  • Human whole blood incubated with xenon (65%) or halothane.
  • Platelet activation and glycoprotein expression analyzed via flow cytometry.
  • Platelet function analyzer (PFA-100) assessed hemostasis under shear stress.

Main Results:

Related Experiment Videos

  • Xenon did not alter basal or agonist-stimulated platelet glycoprotein expression (GPIIb/IIIa, GPIb, P-selectin).
  • Xenon did not affect GPIIb/IIIa activation or PFA closure times.
  • Halothane, however, reduced thrombin receptor agonist peptide-induced GPIIb/IIIa activation and prolonged collagen/epinephrine-induced PFA closure time.

Conclusions:

  • Xenon does not significantly affect platelet glycoprotein expression or function in vitro.
  • Xenon does not impair platelet-related hemostasis at clinically relevant concentrations.
  • Xenon appears to be a safer anesthetic agent regarding platelet function compared to halothane.