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Related Experiment Videos

Polylink: to support two-point linkage analysis in autotetraploids.

Y He1, X Xu, K R Tobutt

  • 1Department of Electronics, University of Kent at Canterbury, Canterbury, Kent CT2 7NF, UK.

Bioinformatics (Oxford, England)
|August 29, 2001
PubMed
Summary

Polylink software facilitates autopolyploid linkage analysis using a random chromosome pairing model. It calculates probabilities, estimates recombination fractions, and offers simulation capabilities for genetic research.

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Area of Science:

  • Genetics
  • Bioinformatics

Background:

  • Polylink is a free software package available via email.
  • It is designed for geneticists and researchers in related fields.

Purpose of the Study:

  • To provide a computational tool for two-point linkage analysis in autopolyploids.
  • To implement calculations based on the random chromosome pairing model.

Main Methods:

  • Utilizes the random chromosome pairing model for analysis.
  • Performs calculations of offspring phenotypic probabilities.
  • Computes theoretical standard errors and maximum likelihood estimates.

Main Results:

  • The software enables investigation of linkage in autopolyploids.
  • It offers numerical computation of maximum likelihood estimates.

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  • Includes simulation facilities for further analysis.

    • Conclusions:

    • Polylink runs on Microsoft Windows (95 or later).
    • It is a versatile tool for genetic linkage analysis in autopolyploids.
    • The software supports various calculations and simulations.