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Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys
V Khavinson1, N Goncharova, B Lapin
1St. Petersburg Institute of Bioregulation and Gerontology, 3 Dynamo Prospect, 197110 St. Petersburg, Russia. ibg@medport.ru
Neuro Endocrinology Letters
|August 29, 2001
Abstract
Unlabelled:
The OBJECTIVE of this research was to investigate the regulatory effect of Epitalon on the production of melatonin and cortisol in senescent monkeys.
Material And Methods:
We investigated the character of melatonin and cortisol secretion by immunoferment assay in Epitalon-administered female Macaca mulatta in different age periods.
Results:
Epitalon was proven to significantly stimulate melatonin synthesis in senescent monkeys in the evening, thereby normalising the circadian rhythm of cortisol secretion.