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[Cotranslational protein folding].

V A Kolb1

  • 1kolb@vega.protres.ru

Molekuliarnaia Biologiia
|August 30, 2001
PubMed
Summary
This summary is machine-generated.

Nascent proteins begin folding on the ribosome during synthesis. This cotranslational folding, observed in all cells, is a universal and ancient protein folding mechanism.

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Area of Science:

  • Molecular Biology
  • Biochemistry
  • Structural Biology

Context:

  • Protein synthesis occurs on ribosomes.
  • Nascent polypeptide chains emerge from the ribosome.
  • Protein folding is crucial for biological function.

Purpose:

  • To review existing research on protein folding during synthesis.
  • To analyze experimental data on nascent protein structure acquisition.
  • To determine the timing and universality of cotranslational folding.

Summary:

  • A significant portion of a protein's spatial structure is acquired while still attached to the ribosome.
  • Final folding into the biologically active conformation occurs upon release from the ribosome.
  • Cotranslational folding is a conserved mechanism in both bacterial and eukaryotic cells.

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Impact:

  • Cotranslational folding is identified as a universal and evolutionarily ancient mechanism.
  • This understanding impacts models of protein biogenesis.
  • Highlights the ribosome's role beyond translation in protein structure formation.