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Severe erectile dysfunction is a marker for hyperprolactinemia.

A M Johri1, J P Heaton, A Morales

  • 1Queen's University, Kingston General Hospital, Ontario, Canada.

International Journal of Impotence Research
|August 30, 2001
PubMed
Summary
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Routine prolactin measurement can help detect hyperprolactinemia in men with erectile dysfunction. Early detection through inexpensive testing may improve treatment outcomes for this serious condition.

Area of Science:

  • Endocrinology
  • Urology
  • Men's Health

Background:

  • The necessity of routine prolactin (PRL) testing in initial erectile dysfunction (ED) evaluations is debated due to low hyperprolactinemia (HP) rates and costs.
  • Sexual desire issues are often considered reliable indicators of HP or low testosterone in men with ED.

Observation:

  • A study evaluated 138 men with ED, measuring PRL and sexual hormones.
  • Severe HP (>35 ng/ml) was found in 2.2% of patients, consistent with previous reports.
  • No correlation was observed between initial PRL levels and the sexual desire or erectile function domains of the International Index of Erectile Function (IIEF).

Findings:

  • All severe HP cases occurred in men scoring below 10 on the IIEF's Erectile Function Domain (EFD).
  • HP was identified in patients without reported sexual desire disorders, challenging the assumption that low libido is a prerequisite.

Related Experiment Videos

  • Clinically significant HP was not detected in men with EFD scores above 10.

    • Implications:

    • Routine, inexpensive prolactin testing can reliably identify clinically significant HP in men with ED.
    • Early detection of HP can lead to better therapeutic success for a serious, treatable condition.
    • The findings suggest that prolactin measurement is valuable even in the absence of overt sexual desire problems.